Guy-Manuel De Homem Christo was born on February 8th, 1974 in the Paris suburb of Neuilly-sur-Seine. He is of Portuguese aristocratic descent: his great-grandfather was the writer and fascism advocate Homem Cristo Filho, whose father was the military figure Francisco Manuel Homem Cristo. He also has a younger brother, Paul de Homem-Christo.
He stated in an interview when he was 7 years old he was given a toy guitar and a keyboard and was given an electric guitar at 14. He expresses he uses the guitar when writing music. He met Thomas Bangalter in school and quickly became friends due to their mutual fascination with films and music of the 1960s and 70s. Eventually, Guy-Manuel, Thomas Bangalter, and Laurent Brancowitz formed Darlin', an indie rock band that was short lived. A negative review in Melody Maker referred to the act as "A bunch of daft punky thrash", to which they find the review amusing. This led to the disbanding of Darlin'.
After the disbanding of Darlin' Guy and Thomas became interested in electronic music after going into a club in 1992 and formed Daft Punk. Guy is credited for creating the Daft Punk logo.
Besides Daft Punk work he is the co-founder of the group Le Knight Club which include himself and Eric Chedeville from Pumpking Records. Both are the founder of the record label Crydamoure, named after a variation of the French phrase "cri d'amour" or "cry of love" in English. Crydamoure also published works by Homem-Christo's brother Paul de Homem-Christo, under the name Play Paul. In regards to Crydamoure, Guy-Manuel stated:
"Myself and Thomas have the same tastes in music. When I make records for Crydamoure it's a different style than what may end up as Daft Punk music. I know what Thomas likes, and he knows what I like. Crydamoure is not so production oriented, even if it's not too far from Daft Punk. The Daft Punk material is more orchestrated and slightly different. I may be working on a sample for Crydamoure, and maybe no one else can hear the difference, but we know. It's very precise." 
Guy-Manuel produced Sébastien Tellier's 2008 album titled Sexuality. Tellier remarks that Guy-Manuel is very comfortable to work with, as he later collaborated on Tellier's 2012 album My God Is Blue, producing the track "My Poseidon".
"I don’t need to talk to Guy-Man, you know? We are in studio, we work, but we don’t talk, just the silence of music, but no words, and it’s very comfortable to me, because I don’t like to explain when I am waiting in the studio, “Oh, more like that,” or “no, no, more like that.” I want to work in a direct way." 
In interviews, Guy-Manuel is less talkative at length in comparison to Thomas, but is prone to random outbursts and one-liners. This has been noted to be, at least in the beginning, because his English was not as fluent as Thomas'. Generally, he comes across as very 'grumpy' and 'disinterested' to interviewers.
In regard of collaborations with other artists, he sees it as a matter of timing and creativity instead of fame and opportunity. He says in an interview:
|“||Well that depends on what we want to do at the time. It depends. I don’t know. Yeah, exactly. There are all these considerations you’re talking about. But yes, it just depends on the moment you’re asked. If you feel it and if you feel something creatively interesting then it’s possible. For everything that we’re asked to do, if we have a creative answer and think we might bring something to a project then we can do it. But if we don’t have any ideas or don’t think we can push the envelope by creating with anybody... Well, if you take Sebastien Tellier for example it is one of the few collaborations where I had the idea that I could do something and bring something to it. But it’s all about the moment and the situation. When it feels right to us, when we feel it we do it, and when we have the time. There’s so many factors.[Citation needed]||”|
- as Producer
- 2018: "Hurt You" by The Weeknd
- 2017: Rest by Charlotte Gainsbourg
- 2013: "OutRun" by Kavinsky
- 2010: "Nightcall" by Kavinsky
- 2008: "Sexuality" by Sébastien Tellier
- 2004: "Stay" by David Guetta
- ↑ Daft Punk Musique Vol. 1 Official Site
- ↑ Perron, Erwan, and Gancel, Alice (7 April 2013). "Daft Punk, interview-fleuve pour la sortie de Random Access Memories". Telerama (in French). telerama.fr. Retrieved 7 April 2013.
- ↑ Weiner, Jonah (21 May 2013). "Daft Punk: All Hail Our Robot Overlords". Rolling Stone. Retrieved 21 May 2013.
- ↑ "Bas les casques - Le vrai visage de Daft Punk"
- ↑ https://consequenceofsound.net/2015/05/daft-punks-guy-manuel-de-homem-christo-revives-le-knight-club-listen-to-new-song-the-fight/
- ↑ http://roninasylum.com/news/robopop/
- ↑ http://anthemmagazine.com/qa-with-sebastien-tellier/
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